Miami International Holdings co-led an $11.4m round for Ledger Holdings, which is awaiting regulatory approval for its bitcoin options exchange LedgerX.

GV led a round that included Salesforce Ventures, increasing the total raised by the customer engagement analytics platform to more than $25m.

Lilly Ventures and Mitsui Global Investment reinvested in a $30m round for Symic that will support a phase 3 trial for a compound intended to improve vein graft surgery.

Comcast Ventures joined three more returning investors for a $20m series B round that will support the luggage e-commerce player's expansion into media and live stores.

GV, which led the electronic distance logging app developer's seed round in 2013, has come back to invest in its latest round, which took the company's total funding to $28m.

Cloud workspace software provider Frame has now raised $32m altogether, after Microsoft Ventures came on board as an investor.

The online real estate services platform has raised $19.5m from Daily Mail and General Trust as well as the Savills-backed Grosvenor Ventures, which led its series A last year.

Automotive cybersecurity startup Karamba has collected $12m in series B capital from a consortium that included Liberty Mutual, Sumitomo and Asgent.