Joseph Doyle, Brainlab's chief financial officer, said: "Jan Medical is introducing an entirely new field of diagnostics that can impact everything from patient triage to surgical treatment."

Fidelity Biosciences and private equity firm TPG Biotech co-lead $45m A round for Ultragenyx Pharmaceutical.

AMmantX was spun off last year from Expert System and has gained Intesa venture backing.

Alongside Citi Growth Ventures & Innovations in the A round for ReadyForZero were venture capital firm Polaris Venture Partners and angel investors.

Chinese website 55tuan.com is reporedly raising $200m from Zero2IPO, Goldman Sachs and others.

Alongside Geisinger's corporate venturing unit in the round were venture capital firms Novitas Capital and the Pittsburgh Life Science Greenhouse.

Partners Healthcare, a US-based medical services provider, has spun off Hop Skip Connect, which has been renamed Healthrageous and raised $6m from venture capital firms North Bridge Venture Partners, Egan Managed Capital and Long River Ventures.

Accelerator said Oncofactor was its first investment based on internal intellectual property developed at the group.

James Posada, chief executive of Resolve, said: "We are very pleased to close this initial $2m of our series A financing and expect to complete the round with a third, corporate investor in the near future."

Covagen spun out of technology university ETH Zurich in 2007 with local drugs group Novartis' backing and previously raised an undisclosed amount from Novartis Venture Fund and MPH, the corporate venturing unit of Japan's Mitsubishi Tanabe Pharma (MTP) and Mitsubishi Chemical, in October 2009.