The pharmaceutical company, which is developing treatments for ear disorders, has now secured more than $143m in total from backers including Novo.

The Michigan University start-up has entered an agreement with Medivation.

The UCLA immuno-oncology specialist has raised the money from a group of private investors.

DNA Electronics has raised the funding required to develop a line of semiconductor-based diagnostic testing products, with main shareholder Genting Berhad providing most of the cash.

The company, which develops treatments for cancer and infectious diseases, has set the range for its initial public offering two years after it was suspended.

Genting Berhad's investment will enable the company to develop its Genalysis point-of-care genomic diagnostic product line.

Corporates SAP Ventures, Red Hat and Quest all exited through the deal, after Jaspersoft raised $43.5m between 2005 and 2011.

The France-based medical software developer has now secured almost $40m in funding since it was founded in 2001.

SI-Bone, which has developed a device to treat lower back pain, will now seek to expand beyond the US into more than a dozen other markets.