The medical device producer joined Trice Medical's existing investors in a $19.3m series C round that took the orthopaedic diagnostics technology provider's overall funding above $40m.

Comcast Cable, Samsung Venture Investment Corporation, Presidio Ventures, Liberty Global Ventures and Shaw Ventures contributed to a round that took Plume's total funding to $63m.

Stapled peptide developer Aileron Therapeutics has filed for a $69m IPO that will allow Roche, Novartis, GlaxoSmithKline and Eli Lilly to exit.

The Duke University spinout has secured capital from 10 unnamed investors.

Spun out of Queensland and Emory universities, the biotech developer has secured capital from Uniseed and the Medical Research Commercialisation Fund.

Grail, the Illumina spinout backed by Bristol-Myers Squibb, Celgene, Merck & Co, Johnson & Johnson, Varian, McKesson, Amazon and Tencent, has agreed to merge with Cirina.

PhiSkin has raised $17.7m in a series B round led by Legend Capital and will use the funding to expand its range of cosmetic treatment centres across China.

The Pfizer and Takeda-backed breast cancer therapy developer has filed to raise $75m in an initial public offering that follows some $130m in equity financing.

The advanced hearing aid developer has closed a round featuring Medtronic and Cochlear at $73m, and secured a $45m debt facility.

Existing shareholders, including IP Group and Finance Wales, have supplied additional capital to Cardiff spinout Alesi Surgical.